Journal of Emerging Trends in Engineering and Applied Sciences: Research Areas

Article Title: IN - VITRO SYNERGISTIC ACTIVITY OF EUPHORBIA BALSAMIFERA ROOT EXTRACT AND AMPICLOX AGAINST SOME PATHOGENIC BACTERIAL ISOLATE
by I., Sunusi

Abstract:
Euphorbia Balsamifera (root) was collected, identified, air-dried, ground and extracted by cool- extraction using mercerization method. Standard phytochemical tests of Trease and Evans was adopted for the phytochemical screening which revealed the presence of Terpenoids, Anthraquinones, Flavonoids, Saponins, Tannins, Alkaloids and Cardiac glycosides. The Minimum Inhibitory Concentration of methanolic extract in combination with Ampiclox using 3 different clinical pathogenic Bacterial isolates was found to be 15mg/ml to 34.7mg/ml. The highest synergistic activity was attained against Escherichia Coli. This result indicated strong antibacterial activity of the methanolic extract in combination with Ampiclox against the pathogenic Bacterial isolates. The spectra of antimicrobial activities displayed by the methanolic extract alone and methanolic extract in combination with Ampiclox could be attributed to the presence of these phytochemicals and this signified the potential of the plant to serve as a source of therapeutic agents.

Keywords: synergism, phytochemical, ampiclox, pathogenic bacterial isolates, in-vitro.

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