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Journal of Emerging Trends in Engineering and Applied Sciences (JETEAS)
ISSN:2141-7016
| Abstract: The use of functional foods and their bioactive constituents have been considered as a new approach in the prevention and management of type-2 diabetes and its complications.This study sought to evaluate the antidiabetic potentials of jute leaf (Corchorus olitorius) on low dose streptozotocin/high fat diet induced diabetic rats. In this study, average food intake, average weight, blood glucose, intestinal alpha-glucosidase, pancreatic alpha-amylase, lung angiotensin-1-converting enzyme activities, lipid peroxidation in pancreas, total cholesterol and triglyceride were measured. NTPDase, 5´-nucleotidase and adenosine deaminase activities were also examined in the platelets of diabetic rats. The results showed that there was a significant increase (P<0.05) in the blood glucose, ?-amylase, ?-glucosidase, angiotensin-1-converting enzyme activities, lipid peroxidation in pancreas, total cholesterol and triglyceride levels in diabetic rats when compared to the normal (control) rats. However, the supplementation of 10% of jute leaf showed a significant reduction (P<0.05) of these biochemical parameters when compared to the diabetic control group. Furthermore, the dietary inclusion of this vegetable also significantly increased (P<0.05) ATP, ADP and AMP hydrolyses except for adenosine hydrolysis in the platelets of diabetic rats when compared to the diabetic control group. In conclusion, the supplementation of vegetable diet in type-2 diabetic rats showed antihyperglycemic, antihyperlipidemic and antiperoxidative effects. It also exhibited modulatory effects on purinergic enzymes involved in the prevention of platelet abnormality and consequent vascular complications in diabetic state. Thus, this vegetable could be a good source of functional food for dietary intervention in the management of type-2 diabetes and its associated complications. |
| Keywords: jute, antihyperglycemic, antihyperlipidemic, antiperoxidative, type-2 diabetic rats |
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